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Effects of diphenylhydantoin on coronary and systemic haemodynamics in awake dogs

Howard J. Zeft, Judith C. Rembert, Cynthia J. Curry, J. C. Greenfield

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Abstract

In the intact conscious dog, DPH(5 mg/kg) produced an increase of 30 ± 4% in heart rate and 61 ± 10% in coronary blood flow. With the heart rate controlled by ventricular pacing, a similar dose of DPHproduced an increase in coronary blood flow of 57 ±7%. There was no significant change in either aortic blood flow or peripheral vascular resistance. These haemodynamic effects were not altered by beta-receptor blockade. From these data it is concluded that DPHhas a transient, direct vasodilating effect on the coronary circulation.

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What this paper is about

In the intact conscious dog, DPH(5 mg/kg) produced an increase of 30 ± 4% in heart rate and 61 ± 10% in coronary blood flow. With the heart rate controlled by ventricular pacing, a similar dose of DPHproduced an increase in coronary blood flow of 57 ±7%. There was no significant change in either aortic blood flow or peripheral vascular resistance. These haemodynamic effects were not altered by beta-receptor blockade. From these data it is concluded that DPHhas a transient, direct vasodilating effect on the coronary circulation.

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Available abstract

In the intact conscious dog, DPH(5 mg/kg) produced an increase of 30 ± 4% in heart rate and 61 ± 10% in coronary blood flow. With the heart rate controlled by ventricular pacing, a similar dose of DPHproduced an increase in coronary blood flow of 57 ±7%. There was no significant change in either aortic blood flow or peripheral vascular resistance. These haemodynamic effects were not altered by beta-receptor blockade. From these data it is concluded that DPHhas a transient, direct vasodilating effect on the coronary circulation.

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Effects of diphenylhydantoin on coronary and systemic haemodynamics in awake dogs — Research Paper | ScholarLens