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2005•Journal of Pharmacy Practice and ResearchRequires access

Thiopurines for Inflammatory Bowel Disease: Role of Pharmacogenetics

Asmar F. Al Hadithy, Mark Naunton, J. R. B. J. Brouwers

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Abstract

ABSTRACT There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S‐methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior‐to ‐treat pharmacogenetic testing for the thiopurines in practice.

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What this paper is about

ABSTRACT There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S‐methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior‐to ‐treat pharmacogenetic testing for the thiopurines in practice.

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Available abstract

ABSTRACT There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S‐methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior‐to ‐treat pharmacogenetic testing for the thiopurines in practice.

Key concepts: Pharmacogenetics, Thiopurine methyltransferase, Medicine, Inflammatory bowel disease, Pharmacology, Disease, Internal medicine, Genotype

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