2007•Microbiology and ImmunologyOpen access

The Potent Antibacterial Activity of Sitafloxacin against Fluoroquinolone‐Resistant Clinical Isolates of Vibrio cholerae O1

Jun Okuda, Thandavarayan Ramamurthy, Shinji Yamasaki

Abstract

The in vitro antibacterial activity of sitafloxacin using clinical isolates of Vibrio cholerae O1 was compared to other fluoroquinolones: ciprofloxacin, ofloxacin, sparfloxacin and levofloxacin. Against fluoroquinolone-resistant O1 strains, sitafloxacin was 4- to 16-fold more effective than other fluoroquinolones at MIC(90*). Against fluoroquinolone-susceptible O1 strains, the MIC(90) of sitafloxacin was 2- to 4-fold lower than other fluoroquinolones. This suggests sitafloxacin can be used in the treatment of infections caused by V. cholerae O1 strains including the fluoroquinolone-resistant strains.

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Key concepts: Sparfloxacin, Ofloxacin, Ciprofloxacin, Vibrio cholerae, Microbiology, Levofloxacin, Antibacterial agent, Biology