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ACETYLCHOLINESTERASE IN THE FELINE CEREBELLUM

John Whitfield Phillis

Open publisher page 56 citations

Abstract

Abstract— Histochemical procedures for the localisation of AChE have been used on the cerebella of normal and operated cats to investigate the presence of cholinergic pathways. The evidence indicates that some mossy afferent fibres and deep nuclear cells are cholinergic. The presence of AChE in many cells in the granule cell layer suggests that some parallel fibres and association pathways in the cerebellum may also be cholinergic. The relationship of these results to studies on the pharmacology and distribution of choline acetyltransferase in the cerebellum is discussed.

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What this paper is about

Abstract— Histochemical procedures for the localisation of AChE have been used on the cerebella of normal and operated cats to investigate the presence of cholinergic pathways. The evidence indicates that some mossy afferent fibres and deep nuclear cells are cholinergic. The presence of AChE in many cells in the granule cell layer suggests that some parallel fibres and association pathways in the cerebellum may also be cholinergic. The relationship of these results to studies on the pharmacology and distribution of choline acetyltransferase in the cerebellum is discussed.

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Available abstract

Abstract— Histochemical procedures for the localisation of AChE have been used on the cerebella of normal and operated cats to investigate the presence of cholinergic pathways. The evidence indicates that some mossy afferent fibres and deep nuclear cells are cholinergic. The presence of AChE in many cells in the granule cell layer suggests that some parallel fibres and association pathways in the cerebellum may also be cholinergic. The relationship of these results to studies on the pharmacology and distribution of choline acetyltransferase in the cerebellum is discussed.

Key concepts: Choline acetyltransferase, Cerebellum, Cholinergic, Acetylcholinesterase, Aché, Granule cell, CATS, Neuroscience

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