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2014•Applied Mechanics and MaterialsOpen access

Correlation between Clinicopathology and Expression of Heat Shock Protein 72 in Human Hepatocellular Carcinoma

Yan Fang, Xiaoping Wang, Huan Ping Lin, Bing Xu, Jing Gang Fang, Ke Pei Zhang, Yixin Yang

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Abstract

Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of hepatocellular carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 expression was significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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What this paper is about

Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of hepatocellular carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 expression was significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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Available abstract

Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of hepatocellular carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 expression was significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

Key concepts: Hepatocellular carcinoma, Heat shock protein, Immunohistochemistry, Metastasis, Infiltration (HVAC), Lymph node metastasis, Pathology, Cancer research

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Correlation between Clinicopathology and Expression of Heat Shock Protein 72 in Human Hepatocellular Carcinoma — Research Paper | ScholarLens