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DETECTION OF PANCREATIC ISLET TISSUE FOLLOWING ISLET ALLOTRANSPLANTATION IN MAN

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Abstract

Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1).The ultimate test of viability is functional activity after transplantation into a diabetic recipient.Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results.Recently.several centers reported prolonged insulin independence after human islet allotransplantation (2-5).The present report describes the first identification of islet tissue in a liver biopsy after intrahepatic islet allotransplanta-" • •'":•-r~• ':-'" .~~~ .........

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Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1).The ultimate test of viability is functional activity after transplantation into a diabetic recipient.Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results.Recently.several centers reported prolonged insulin independence after human islet allotransplantation (2-5).The present report describes the first identification of islet tissue in a liver biopsy after intrahepatic islet allotransplanta-" • •'":•-r~• ':-'" .~~~ .........

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Available abstract

Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1).The ultimate test of viability is functional activity after transplantation into a diabetic recipient.Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results.Recently.several centers reported prolonged insulin independence after human islet allotransplantation (2-5).The present report describes the first identification of islet tissue in a liver biopsy after intrahepatic islet allotransplanta-" • •'":•-r~• ':-'" .~~~ .........

Key concepts: Allotransplantation, Islet, Medicine, Pancreatic islets, Internal medicine, Transplantation, Endocrinology, Diabetes mellitus

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