Treatment of Neonatal Osteomyelitis with Cloxacillin in Combination with Fusidic Acid

Four immature infants developed staphylococcal neonatal osteomyelitis. In spite of standard treatment with cloxacillin, gentamicin and surgical drainage new lesions developed in all 4 patients. Following the addition of fusidic acid no further progress was seen in any of the infants. Fusidic acid was administered intravenously for 10-14 days in a dose of 40 mg/kg/day in 2 divided doses. The therapy was well tolerated. Thoracic kyphosis in one patient was the only sequelae seen.