2010•ORLRequires access
Flunarizine and Cinnarizine as Vestibular Depressants
Pedro Luiz Mangabeira Albernaz, Maurício Malavasi Ganança, Neil Ferreira Novo, Elias Rodrigues de Paiva
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Abstract
The authors analysed the vestibular depressant activity of flunarizine and cinnarizine, as compared to a placebo, in 58 patients with peripheral labyrinthine disorders. The activity of the medications was judged by the reduction of the average velocity of the slow phase of the post-caloric nystagmus, before and after treatment. In spite of being administered in a smaller dosis, flunarizine appeared to have a more intense vestibular supressant activity, as judged by different statistical tests.