2002•Annals of NeurologyRequires access

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

John E. Duda, Benoit I. Giasson, Meghann E. Mabon, Virginia M.‐Y. Lee, John Q. Trojanowski

Abstract

Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.

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Key concepts: Lewy body, Dementia with Lewy bodies, Parkinsonism, Alpha-synuclein, Pathology, Dementia, Parkinson's disease, Degenerative disease