1954•Canadian Journal of MicrobiologyRequires access

MYCOBACTERIUM TUBERCULOSIS AND CANDIDA ALBICANS: A STUDY OF GROWTH-PROMOTING FACTORS

E. Mankiewicz

Abstract

A new growth factor for Mycobacterium tuberculosis is described. It is produced by Candida albicans and stimulates the growth of tubercle bacilli of reduced viability or multiplication rate, as this is observed after treatment of the patient by chemotherapeutic or antibiotic agents. A method for the earlier detection of M. tuberculosis growing on Loewenstein's medium is described: Loewenstein's culture media, previously inoculated with the pathological specimen suspected to contain tubercle bacilli, are superinoculated with suspensions of Candida albicans whose dependence upon the presence of tubercle bacilli to grow on this medium has been enhanced. Colonies of Candida albicans will "trace" the presence of M. tuberculosis.

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Key concepts: Bacilli, Candida albicans, Mycobacterium tuberculosis, Microbiology, Tubercle, Tuberculosis, Mycobacterium, Biology