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1982•British Journal of DermatologyRequires access

Suppression of alcohol-induced flushing by a combination of H1 and H2 histamine antagonists

Ou Tan, Timothy J. Stafford, I. Sárkány, Peter Michael Gaylarde, C. TILSEY, J. P. Payne

Open publisher page 9 citations

Abstract

Alcohol‐induced flushing of the face and neck regions is a well recognized condition, probably genetically determined and due to individual differences in alcohol metabolism. We have shown that the flushing appears only after a threshold level of blood alcohol (20–35 mg per 100 ml) is exceeded. The rate of alcohol absorption and peak blood levels were reduced by a combination of H1 and H2 antagonists. This reduction was accompanied by abolition of flushing in sensitive individuals.

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What this paper is about

Alcohol‐induced flushing of the face and neck regions is a well recognized condition, probably genetically determined and due to individual differences in alcohol metabolism. We have shown that the flushing appears only after a threshold level of blood alcohol (20–35 mg per 100 ml) is exceeded. The rate of alcohol absorption and peak blood levels were reduced by a combination of H1 and H2 antagonists. This reduction was accompanied by abolition of flushing in sensitive individuals.

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OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Alcohol‐induced flushing of the face and neck regions is a well recognized condition, probably genetically determined and due to individual differences in alcohol metabolism. We have shown that the flushing appears only after a threshold level of blood alcohol (20–35 mg per 100 ml) is exceeded. The rate of alcohol absorption and peak blood levels were reduced by a combination of H1 and H2 antagonists. This reduction was accompanied by abolition of flushing in sensitive individuals.

Key concepts: Flushing, Alcohol, Histamine, Histamine antagonists, Absorption (acoustics), Ethanol, Blood alcohol, Medicine

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