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Postnatal development of brain TRH, serum TSH and thyroid hormones in the male and female rat

Lucía Rodríguez Gayo, Bartolomé Bonet, Arantxa Herranz, Roser Iglesias, M.J. Toro, Erin McConnell Montoya

Open publisher page 26 citations

Abstract

The postnatal development of immunoreactive TRH in the central nervous system (CNS), serum TSH and thyroid hormones was studied in both male and female normal rats. While in most structures of the CNS, TRH increased until day 20-30, serum TSH values peaked at day 15 as did T4. Significant differences were also obtained between both sexes in these parameters. These data further support the fact that pituitary-thyroid axis maturation is independent of brain TRH.

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What this paper is about

The postnatal development of immunoreactive TRH in the central nervous system (CNS), serum TSH and thyroid hormones was studied in both male and female normal rats. While in most structures of the CNS, TRH increased until day 20-30, serum TSH values peaked at day 15 as did T4. Significant differences were also obtained between both sexes in these parameters. These data further support the fact that pituitary-thyroid axis maturation is independent of brain TRH.

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Available abstract

The postnatal development of immunoreactive TRH in the central nervous system (CNS), serum TSH and thyroid hormones was studied in both male and female normal rats. While in most structures of the CNS, TRH increased until day 20-30, serum TSH values peaked at day 15 as did T4. Significant differences were also obtained between both sexes in these parameters. These data further support the fact that pituitary-thyroid axis maturation is independent of brain TRH.

Key concepts: Internal medicine, Endocrinology, Hormone, Thyroid hormones, Medicine, Thyroid, Brain development, Biology

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