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1978•European Journal of EndocrinologyRequires access

THE EFFECT OF OOPHORECTOMY ON PLASMA OESTRONE AND ANDROSTENEDIONE LEVELS IN THE RAT

Michael E. Fearnley, Alison J Hodgkinson, Alexandra L. Holmes, B. E. C. Nordin

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Abstract

Plasma oestrone and androstenedione levels have been measured in oophorectomized and sham-operated rats by means of radioimmunoassay. The mean oestrone level in the oophorectomized animals was approximately two-thirds of that in the intact animals while the androstendione levels were about half of those in the intact rats. A direct relationship was observed between the plasma oestrone and androstenedione levels in the control animals and to a lesser extent in the oophorectomized animals. The results indicate that approximately 50% of circulating androstenedione and 30% of circulating oestrone originate in the ovaries in the female adult rat.

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What this paper is about

Plasma oestrone and androstenedione levels have been measured in oophorectomized and sham-operated rats by means of radioimmunoassay. The mean oestrone level in the oophorectomized animals was approximately two-thirds of that in the intact animals while the androstendione levels were about half of those in the intact rats. A direct relationship was observed between the plasma oestrone and androstenedione levels in the control animals and to a lesser extent in the oophorectomized animals. The results indicate that approximately 50% of circulating androstenedione and 30% of circulating oestrone originate in the ovaries in the female adult rat.

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Available abstract

Plasma oestrone and androstenedione levels have been measured in oophorectomized and sham-operated rats by means of radioimmunoassay. The mean oestrone level in the oophorectomized animals was approximately two-thirds of that in the intact animals while the androstendione levels were about half of those in the intact rats. A direct relationship was observed between the plasma oestrone and androstenedione levels in the control animals and to a lesser extent in the oophorectomized animals. The results indicate that approximately 50% of circulating androstenedione and 30% of circulating oestrone originate in the ovaries in the female adult rat.

Key concepts: Androstenedione, Internal medicine, Endocrinology, Radioimmunoassay, Oophorectomy, Plasma levels, Estrone, Chemistry

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