2006•Nucleosides Nucleotides & Nucleic AcidsRequires access

Deamination of 2′,3′-O-Isopropylideneadenosine-5′- Carboxylic Acid Catalyzed by Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA): Influence of Substrate Ionization on the Activity of the Enzymes

Pierangela Ciuffreda, Laura Alessandrini, Radmila Pavlović, Enzo Santaniello

Abstract

Adenosine deaminase (ADA) and adenylate deaminase (AMPDA) catalyze the deamination of 2 ',3 '-O-isopropylideneadenosine-5'-carboxylic acid to the corresponding inosine derivative and dependence of the rate of enzymatic reaction on the ionization degree of the substrate has been studied at different pH values.

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Key concepts: Deamination, Inosine, Adenosine deaminase, Substrate (aquarium), AMP deaminase, Chemistry, Enzyme, Adenylate kinase