The Nephrotic Syndrome

RECENT advances in knowledge of the nature of the nephrotic syndrome have led to more rational therapy. The purpose of this communication is to review this progress.The nephrotic syndrome is a clinical entity characterized by massive proteinuria, hypoproteinemia, hypoalbuminemia and hyperlipidemia, with or without edema, hematuria, hypertension and azotemia.Students of the disorder are urged to read Leiter's1 scholarly monograph, published in 1931, the critical discussion of the pathogenesis of various manifestations of the nephrotic syndrome presented as a Medical Progress report in this journal in 1948 by Bradley and Tyson,2 Allen's3 recent stimulating paper on the "Clinicopathologic meaning . . .