1989•Journal of Computer Assisted TomographyRequires access

Gadolinium-phthalein Complexone as a Contrast Agent for Hepatobiliary MR Imaging

Yasutaka Kawamura, Keigo Endo, Mitsuru Koizumi, Yuji Watanabe, Tsuneo Saga, Junji Konishi, Kazuko Horiuchi, Akira Yokoyama

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Abstract

Gadolinium-phthalein complexone (Gd-PC) was developed as a hepatobiliary magnetic resonance (MR) contrast agent. Phthalein complexone is one of the iminodiacetic acid derivatives and a structural analogue of bromosulfophthalein. Gadolinium-PC substantially enhanced signal intensity of normal functioning livers on T1-weighted MR images. Contrast enhancement of rabbit liver and gradual accumulation of high intensity bile in the gallbladder were observed after intravenous injection of 0.05 and 0.1 mmol/kg Gd-PC. However, 0.1 mmol/kg of Gd-DTPA caused little effect on liver MR.

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Available abstract

Key concepts: Gadolinium, Medicine, Magnetic resonance imaging, Gadolinium DTPA, Iminodiacetic acid, MRI contrast agent, Gallbladder, Contrast (vision)