ScholarLens Back to search
1970•Proceedings of the National Academy of SciencesOpen access

A Cell-Associated Factor Essential for Formation of an Infectious Form of Rous Sarcoma Virus

Hidesaburô Hanafusa, Tsutomu Miyamoto, Terukiyo Hanafusa

Open full text 141 citations

Abstract

Formation of a specific type of infectious Rous sarcoma virus called RSV(0) has been found to occur only in a certain type of chick embryo cell in the absence of avian leukosis virus. Although these chick cells lack any complete form of avian leukovirus, they appear to carry a genetic factor essential for formation of infectious RSV(0). A factor-deficient cell can be converted to a producer of infectious RSV(0) by infection with Rous sarcoma virus or avian leukosis virus which has been grown in factor-containing cells. Evidence is presented to show that the factor determines both the antigenic and host range specificity of RSV(0).

About this research paper

What this paper is about

Formation of a specific type of infectious Rous sarcoma virus called RSV(0) has been found to occur only in a certain type of chick embryo cell in the absence of avian leukosis virus. Although these chick cells lack any complete form of avian leukovirus, they appear to carry a genetic factor essential for formation of infectious RSV(0). A factor-deficient cell can be converted to a producer of infectious RSV(0) by infection with Rous sarcoma virus or avian leukosis virus which has been grown in factor-containing cells. Evidence is presented to show that the factor determines both the antigenic and host range specificity of RSV(0).

Why it matters

OpenAlex reports 141 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Formation of a specific type of infectious Rous sarcoma virus called RSV(0) has been found to occur only in a certain type of chick embryo cell in the absence of avian leukosis virus. Although these chick cells lack any complete form of avian leukovirus, they appear to carry a genetic factor essential for formation of infectious RSV(0). A factor-deficient cell can be converted to a producer of infectious RSV(0) by infection with Rous sarcoma virus or avian leukosis virus which has been grown in factor-containing cells. Evidence is presented to show that the factor determines both the antigenic and host range specificity of RSV(0).

Key concepts: Rous sarcoma virus, Virology, Biology, Virus, Embryo, Viral transformation, Oncovirus, Genetics

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A Cell-Associated Factor Essential for Formation of an Infectious Form of Rous Sarcoma Virus — Research Paper | ScholarLens