2003•Journal of Clinical MicrobiologyOpen access

babA2- and cagA -Positive Helicobacter pylori Strains Are Associated with Duodenal Ulcer and Gastric Carcinoma in Brazil

Adriana Gonçalves de Oliveira, Adriana Santos, Juliana Becattini Guerra, Gifone Aguiar Rocha, Andréia Maria Camargos Rocha, Celso Affonso de Oliveira, Mônica Maria Demas Álvares Cabral, Ana Margarida Miguel Ferreira Nogueira, Dulciene Maria Magalhães Queiroz

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Abstract

The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between babA2 and duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, and cagA status. cagA-positive strains were also independently associated with H. pylori-related diseases.

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Key concepts: CagA, Helicobacter pylori, Gastroenterology, Spirillaceae, Duodenal ulcer, Gastric carcinoma, Internal medicine, Confounding