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2014•Angewandte Chemie International EditionRequires access

“Post‐It” Type Connected DNA Created with a Reversible Covalent Cross‐Link

María Tomás‐Gamasa, Sascha Serdjukow, Meng Su, Markus Müller, Thomas Carell

Open publisher page 33 citations

Abstract

We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.

About this research paper

What this paper is about

We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.

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OpenAlex reports 33 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.

Key concepts: Link (geometry), Cross-link, Covalent bond, Duplex (building), DNA, Imine, Chemistry, Nanotechnology

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“Post‐It” Type Connected DNA Created with a Reversible Covalent Cross‐Link — Research Paper | ScholarLens