1999•Acta Biochimica PolonicaOpen access

Lack of squamous cell lung carcinoma in vitro chemosensitivity to various drug regimens in the adenosine triphosphate cell viability chemosensitivity assay.

U Vogt, E Striehn, U. Bosse, F Klinke, Bogdan Falkiewicz

Abstract

A pilot study on squamous cell lung carcinoma (LC) chemosensitivity in adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA) was performed. Besides the histological investigation, a modified ATP-CVA was used for the analysis of cancer cell chemosensitivity to four drug regimens, including topotecan, a promising agent for non-small-cell lung cancer (NSCLC) chemotherapy. Results of in vitro chemosensitivity testing showed chemoresistance or only weak response in the predominant amount of tumors.

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Key concepts: Chemosensitivity assay, Viability assay, Cell, In vitro, Cancer research, Adenosine triphosphate, Cell culture, Chemistry