1998NeurologyRequires access

Albendazole therapy for neurocysticercosis

Hector Hugo Garcia, Santiago Martínez, Genaro Herrera, Robert H. Gilman

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Abstract

Reply from the Authors: The need for placebo-controlled studies in the treatment of neurocysticercosis (NCC) was commented on soon after the introduction of praziquantel as the first antiparasitic drug for this condition.16 Double-blind randomized trials including an untreated placebo group were not instituted because such a study was considered unethical because a drug effective against cysticercosis existed. This view was supported by initial retrospective follow-up series of epileptic neurocysticercosis patients.10,17 Conversely, the scarce available information suggests that parenchymal cysticercosis usually has a self-limited and relatively benign course. In addition, …

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What this paper is about

Reply from the Authors: The need for placebo-controlled studies in the treatment of neurocysticercosis (NCC) was commented on soon after the introduction of praziquantel as the first antiparasitic drug for this condition.16 Double-blind randomized trials including an untreated placebo group were not instituted because such a study was considered unethical because a drug effective against cysticercosis existed. This view was supported by initial retrospective follow-up series of epileptic neurocysticercosis patients.10,17 Conversely, the scarce available information suggests that parenchymal cysticercosis usually has a self-limited and relatively benign course. In addition, …

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Available abstract

Reply from the Authors: The need for placebo-controlled studies in the treatment of neurocysticercosis (NCC) was commented on soon after the introduction of praziquantel as the first antiparasitic drug for this condition.16 Double-blind randomized trials including an untreated placebo group were not instituted because such a study was considered unethical because a drug effective against cysticercosis existed. This view was supported by initial retrospective follow-up series of epileptic neurocysticercosis patients.10,17 Conversely, the scarce available information suggests that parenchymal cysticercosis usually has a self-limited and relatively benign course. In addition, …

Key concepts: Neurocysticercosis, Albendazole, Cysticercosis, Medicine, Praziquantel, Placebo, Antiparasitic agent, Helminthiasis

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