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1977•Biology of ReproductionOpen access

Regulation of LH Secretion in Aged Female Rats1

John J. Peluso, Richard W. Steger, E. S. E. Hafez

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Abstract

Although a relatively low dose of estradiol benzoate (E.B.) suppressed LH levels in both mature and aged ovariectomized (OVX) rats, a higher dose of E.B. induced an LH surge in mature OVX-E.B. primed rats, but failed to do so in aged OVX-E.B. primed rats. GnRH administration, however, was as effective in triggering an LH release in both mature and aged OVX-E.B. primed rats. Therefore, the cessation of reproductive cycles in the aged female rat appears to involve alterations within the “positive estrogen feedback center” of the anterior hypothalamus rather than in the pituitary or “negative estrogen feedback center”.

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What this paper is about

Although a relatively low dose of estradiol benzoate (E.B.) suppressed LH levels in both mature and aged ovariectomized (OVX) rats, a higher dose of E.B. induced an LH surge in mature OVX-E.B. primed rats, but failed to do so in aged OVX-E.B. primed rats. GnRH administration, however, was as effective in triggering an LH release in both mature and aged OVX-E.B. primed rats. Therefore, the cessation of reproductive cycles in the aged female rat appears to involve alterations within the “positive estrogen feedback center” of the anterior hypothalamus rather than in the pituitary or “negative estrogen feedback center”.

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Available abstract

Although a relatively low dose of estradiol benzoate (E.B.) suppressed LH levels in both mature and aged ovariectomized (OVX) rats, a higher dose of E.B. induced an LH surge in mature OVX-E.B. primed rats, but failed to do so in aged OVX-E.B. primed rats. GnRH administration, however, was as effective in triggering an LH release in both mature and aged OVX-E.B. primed rats. Therefore, the cessation of reproductive cycles in the aged female rat appears to involve alterations within the “positive estrogen feedback center” of the anterior hypothalamus rather than in the pituitary or “negative estrogen feedback center”.

Key concepts: Ovariectomized rat, Internal medicine, Endocrinology, Estrogen, Estradiol benzoate, Biology, Hypothalamus, Medicine

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