e0626 The effects of recombinant human B-type natriuretic peptid on coronary circulation and renal haemodynamics in York pigs model of acute myocardial infarction with heart failure

Objective To evaluate the impact of intravenous administration of rhBNP on coronary and renal artery haemodynamics in York pigs model of AMI-ADHF. Methods Fourteen York pigs were included in this study. After the AMI-ADHF models were established, pigs were randomised into saline group and rhBNP group. Coronary pressure (Pc), the average peak velocity (APV), coronary vascular resistance (CR), coronary flow reserve (CFR) and coronary diameter were recorded simultaneously at baseline, instant after the model established, 60 min after continuous infusion of 0.01 μg·kg−1·min−1 rhBNP and the time point of LVEDP<12 mm Hg. The blood flow of the coronary were measured at rest and maximal hyperaemia. Renal angiography was performed by 4F catheter and quantitative measurement of diameter was recorded by the computer assisting system. The average peak rate of renal artery (APVra) was recorded, determination of quantitative angiography of renal artery diameter, renal vascular resistance. LVEDP and LVEF was measured. Results 1. Coronary artery diameter increased after rhBNP administration. APV and CBF were significantly increased and CR decreased after rhBNP administration. CFR was significant rebound after continuous infusion of 0.01 μg·kg−1·min−1 rhBNP for 30min. APV and CBF significantly increased and CR significantly decreased at the stage of infusion 0.010 μg kg−1 min−1 rhBNP in rhBNP Group. 2. Renal artery pressure was significantly lower after rhBNP administration. RhBNP exerts renal vasodilator effects in a dose related relationship. RBF increased gradually after administration of rhBNP and was significantly higher than control group. RVR decreased after administration of rhBNP. LVEF was lower than baseline after the models established and tended to increase after administration of rhBNP. Conclusion It could increase blood flow of injury coronary artery, improve CFR and improve the coronary and renal haemodynamics after intravenous administration of rhBNP in pigs with AMI-ADHF.