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2011•Journal of Medicinal ChemistryRequires access

Important Role of Oxidative Stress Biomarkers in Huntington’s Disease

Isaac Túnez, Fernando Sánchez‐López, Eduardo Agüera, Ricardo Fernández‐Bolaños, Francisco Manuel Sánchez, Inmaculada Tasset-Cuevas

Open publisher page 93 citations

Abstract

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

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What this paper is about

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

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OpenAlex reports 93 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

Key concepts: Oxidative stress, Pathogenesis, Antioxidant, Chemistry, Disease, Huntington's disease, Oxidative phosphorylation, Antioxidant capacity

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