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2011•Biochemistry (Moscow) Supplement Series B Biomedical ChemistryRequires access

The study of activity of blood antioxidant enzymes in HIV infection

V. V. Kostyushov, I. I. Bokal, S. A. Petrov

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Abstract

The HIV infection is accompanied by activation of lipid peroxidation, oxidative modification of lipoprotein complexes, and a decrease in activity of blood serum antioxidant enzymes (superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx)). A significant increase of glutathione reductase observed under these conditions is considered as the antioxidant defense function. These changes are observed at already stages of this disease (in HIV carriers), however, they were much more pronounced in patients with manifested forms of AIDS.

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What this paper is about

The HIV infection is accompanied by activation of lipid peroxidation, oxidative modification of lipoprotein complexes, and a decrease in activity of blood serum antioxidant enzymes (superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx)). A significant increase of glutathione reductase observed under these conditions is considered as the antioxidant defense function. These changes are observed at already stages of this disease (in HIV carriers), however, they were much more pronounced in patients with manifested forms of AIDS.

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Available abstract

The HIV infection is accompanied by activation of lipid peroxidation, oxidative modification of lipoprotein complexes, and a decrease in activity of blood serum antioxidant enzymes (superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx)). A significant increase of glutathione reductase observed under these conditions is considered as the antioxidant defense function. These changes are observed at already stages of this disease (in HIV carriers), however, they were much more pronounced in patients with manifested forms of AIDS.

Key concepts: Human immunodeficiency virus (HIV), Antioxidant, Enzyme, Medicine, Immunology, Virology, Biology, Biochemistry

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