1987•The Japanese Journal of PharmacologyOpen access

Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.

Masanobu Nakahiro, Nobuo Nishi, Isao Fukuchi, Daisuke Mochizuki, Susumu Kato, Atsushi Mizushima, Shuji Uchida, Hiroshi Yoshida

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Abstract

The interactions of the "antidementia drug" pantoyl-gamma-aminobutyric acid (pantoyl-GABA) with gamma-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [3H]GABA to GABAA receptors and those of [3H]baclofen and [3H]GABA to GABAB receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA-receptors in the rat brain.

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Key concepts: GABAB receptor, GABAA receptor, Baclofen, Receptor, gamma-Aminobutyric acid, Chemistry, GABA receptor, GABA receptor antagonist