1998•Reports of Practical Oncology & RadiotherapyOpen access

Large cell anaplastic lypmhoma versus Hodgkin's disease – difficulties in the diagnosis

M Kaczmarek-Kanold, Katarzyna Stefańska, E Trejster, P Kołecki, Grażyna Wróbel, B Sopyło, E Stańczak

Abstract

During the last 5 years in the Polish Children's Leukemia/Lymphoma Study Group (7 centers) 241 children with Hodgkin's Disease and 14 children with Large Cell Anaplastic Lymphoma were treated. In 5 of them we had problems with differential diagnosis. Immunohistochemical tests: CD30 positive, CD15 positive, LCA negative allowed us to change the diagnosis from Large Cell Anaplastic Lymphoma to Hodgkin's Disease (one child) and CD30 positive, CD15 negative from Hodgkin's Disease to Large Cell Anaplastic Lymphoma (four children). All children achieved remission after changing the protocol of chemotherapy.

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Available abstract

Key concepts: CD15, CD30, Anaplastic large-cell lymphoma, Lymphoma, Medicine, Disease, Large cell, Differential diagnosis