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Is the mesocortical dopaminergic system involved in Parkinson disease?

France Javoy‐Agid, Yves Agid

Open publisher page 410 citations

Abstract

Tyrosine hydroxylase was used to identify catecholaminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.

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What this paper is about

Tyrosine hydroxylase was used to identify catecholaminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.

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OpenAlex reports 410 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Tyrosine hydroxylase was used to identify catecholaminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.

Key concepts: Ventral tegmental area, Dopaminergic, Dopamine, Tyrosine hydroxylase, Substantia nigra, Midbrain, Parkinson's disease, Neuroscience

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Is the mesocortical dopaminergic system involved in Parkinson disease? — Research Paper | ScholarLens