ScholarLens Back to search
1972•International Journal of Radiation Biology and Related Studies in Physics Chemistry and MedicineRequires access

Metabolism of NAD after Whole-body Irradiation

G. B. Gerber, J. Deroo

Open publisher page 0 citations

Abstract

SummaryThe metabolism of nicotinamide was investigated in organs of normal and x-irradiated intact rats (24 h after 1000 R whole-body irradiation) and in isolated perfused rat liver. Rates of reactions were calculated from the data on liver perfusion. At low substrate levels, incorporation of nicotinamide seems to involve pathways via nicotinamide mononucleotide, whereas at high substrate levels the Preiss-Handler pathway via nicotinic acid may play a role. The changes after irradiation are explained as the result of an increased catabolism of NAD which cannot be entirely compensated for by re-synthesis.

About this research paper

What this paper is about

SummaryThe metabolism of nicotinamide was investigated in organs of normal and x-irradiated intact rats (24 h after 1000 R whole-body irradiation) and in isolated perfused rat liver. Rates of reactions were calculated from the data on liver perfusion. At low substrate levels, incorporation of nicotinamide seems to involve pathways via nicotinamide mononucleotide, whereas at high substrate levels the Preiss-Handler pathway via nicotinic acid may play a role. The changes after irradiation are explained as the result of an increased catabolism of NAD which cannot be entirely compensated for by re-synthesis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

SummaryThe metabolism of nicotinamide was investigated in organs of normal and x-irradiated intact rats (24 h after 1000 R whole-body irradiation) and in isolated perfused rat liver. Rates of reactions were calculated from the data on liver perfusion. At low substrate levels, incorporation of nicotinamide seems to involve pathways via nicotinamide mononucleotide, whereas at high substrate levels the Preiss-Handler pathway via nicotinic acid may play a role. The changes after irradiation are explained as the result of an increased catabolism of NAD which cannot be entirely compensated for by re-synthesis.

Key concepts: NAD+ kinase, Nicotinamide, Nicotinamide mononucleotide, Metabolism, Catabolism, Whole body irradiation, Substrate (aquarium), Perfusion

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Metabolism of NAD after Whole-body Irradiation — Research Paper | ScholarLens