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1997•Coronary Artery DiseaseRequires access

Thrombin receptor antagonists

Lawrence F. Brass

Open publisher page 24 citations

Abstract

The thrombin receptor and protease-activated receptor 2 (PAR-2) are the two currently known members of the large family of G protein-coupled receptors that are activated by proteases. Both receptors are located on cells in and around the vascular space, including platelets, endothelial cells, vascular smooth muscle cells, fibroblasts and some lymphocytes. This brief review summarizes current information on thrombin receptors and focuses on some of the issues that are relevant for ongoing efforts to develop thrombin receptor antagonists.

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What this paper is about

The thrombin receptor and protease-activated receptor 2 (PAR-2) are the two currently known members of the large family of G protein-coupled receptors that are activated by proteases. Both receptors are located on cells in and around the vascular space, including platelets, endothelial cells, vascular smooth muscle cells, fibroblasts and some lymphocytes. This brief review summarizes current information on thrombin receptors and focuses on some of the issues that are relevant for ongoing efforts to develop thrombin receptor antagonists.

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OpenAlex reports 24 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The thrombin receptor and protease-activated receptor 2 (PAR-2) are the two currently known members of the large family of G protein-coupled receptors that are activated by proteases. Both receptors are located on cells in and around the vascular space, including platelets, endothelial cells, vascular smooth muscle cells, fibroblasts and some lymphocytes. This brief review summarizes current information on thrombin receptors and focuses on some of the issues that are relevant for ongoing efforts to develop thrombin receptor antagonists.

Key concepts: Protease-activated receptor, Thrombin, Thrombin receptor, Receptor, Medicine, Proteases, Cell biology, Protease-activated receptor 2

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