2007•Nucleosides Nucleotides & Nucleic AcidsRequires access

Synthesis of Nucleosides with Additional Nucleobases

Charlotte Uggerhøj Andersen, Søren L. Pedersen, Poul Nielsen

Abstract

The syntheses of two nucleosides with additional nucleobases in the 2'-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The nucleoside with two carbons in the linker has been incorporated into oligonucleotides and showed stabilization of a tree-way junction.

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Key concepts: Nucleobase, Oligonucleotide, Linker, Nucleoside, Chemistry, Combinatorial chemistry, Nucleic acid, DNA