2002•Antimicrobial Agents and ChemotherapyOpen access
Susceptibility to Telithromycin in 1,011 Streptococcus pyogenes Isolates from 10 Central and Eastern European Countries
Kensuke Nagai, Peter C. Appelbaum, Todd A. Davies, Linda M. Kelly, Dianne B. Hoellman, Arjana Tambić Andrašević, Liga Drukalska, Waleria Hryniewicz, Michael R. Jacobs, Jana Kolman, Jolanta Miciulevičienė, Marina Pană, Lena Setchanova, Marianne Konkoly Thege, Helena Hupková, J. Trupl, P Urbášková
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Abstract
Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC(50)s) and the MIC(90)s were as follows: for telithromycin, 0.03 and 0.06 microg/ml, respectively; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 microg/ml, respectively; and for clindamycin, 0.125 and 0.125 microg/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 microg/ml, telithromycin was active against 98.5% of the strains tested.