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1995•Biocatalysis and BiotransformationRequires access

Comparison of the Hydrolysis of CyclicMeso-Diesters with PIG Liver Esterase (PLE) and Rabbit Liver Esterase (RLE)

Peter Renold, Christoph Tamm

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Abstract

A series of cyclic dimethyl meso-dicarboxylates including three-, four-, five- and six-membered rings with various substituents as well as norbornene derivatives were hydrolyzed with pig liver esterase and rabbit liver esterase. No obvious similarity concerning the determined enantioselectivities and reaction half life times was observed comparing the two enzymes. Pig liver esterase was more suitable for producing enantiomerically pure compounds hydrolysing cyclic meso-diesters, whereas rabbit liver esterase showed acceptable ee values only in the case of aliphatic small ring diesters.

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A series of cyclic dimethyl meso-dicarboxylates including three-, four-, five- and six-membered rings with various substituents as well as norbornene derivatives were hydrolyzed with pig liver esterase and rabbit liver esterase. No obvious similarity concerning the determined enantioselectivities and reaction half life times was observed comparing the two enzymes. Pig liver esterase was more suitable for producing enantiomerically pure compounds hydrolysing cyclic meso-diesters, whereas rabbit liver esterase showed acceptable ee values only in the case of aliphatic small ring diesters.

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Available abstract

A series of cyclic dimethyl meso-dicarboxylates including three-, four-, five- and six-membered rings with various substituents as well as norbornene derivatives were hydrolyzed with pig liver esterase and rabbit liver esterase. No obvious similarity concerning the determined enantioselectivities and reaction half life times was observed comparing the two enzymes. Pig liver esterase was more suitable for producing enantiomerically pure compounds hydrolysing cyclic meso-diesters, whereas rabbit liver esterase showed acceptable ee values only in the case of aliphatic small ring diesters.

Key concepts: Esterase, Pig liver, Chemistry, Hydrolysis, Enzyme, Stereochemistry, Biochemistry

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Comparison of the Hydrolysis of CyclicMeso-Diesters with PIG Liver Esterase (PLE) and Rabbit Liver Esterase (RLE) — Research Paper | ScholarLens