2002•Acta HaematologicaRequires access

Apoptosis-Regulating Proteins and Prognosis in Diffuse Large B Cell Non-Hodgkin’s Lymphomas

Kátia Bórgia Barbosa Pagnano, M.D. Silva, José Vassallo, Francisco Aranha, STO Saad

Abstract

We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin's lymphoma, and assessed the relationship of these proteins to clinical outcome and response to chemotherapy. Our results showed that p53 expression was an independent immunohistochemical parameter related to a poor prognosis in these lymphomas. Bcl-2, Bax, Bak and Mcl-1 proteins, though highly expressed in almost all cases were not associated with prognosis or response to treatment.

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Key concepts: Immunohistochemistry, Lymphoma, Apoptosis, Cancer research, BAX Protein, Chemotherapy, Diffuse large B-cell lymphoma, Programmed cell death