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The Chemistry of Eukaryotic Messenger RNA

Tsujiaki Hata, Mitsuo Sekine, Kin‐ichiro Miura

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Abstract

The so-called “cap” structure of the 5′-terminus of eukaryotic messenger RNA (mRNA) is of importance for protein biosynthesis on ribosimes. We have examined the chemical synthesis and structural requirement of the 5′-terminus of mRNA. This paper describes a brief summary of the synthesis of the cap structure and the 5′-terminus of mRNA bearing the leader sequences.

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What this paper is about

The so-called “cap” structure of the 5′-terminus of eukaryotic messenger RNA (mRNA) is of importance for protein biosynthesis on ribosimes. We have examined the chemical synthesis and structural requirement of the 5′-terminus of mRNA. This paper describes a brief summary of the synthesis of the cap structure and the 5′-terminus of mRNA bearing the leader sequences.

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Available abstract

The so-called “cap” structure of the 5′-terminus of eukaryotic messenger RNA (mRNA) is of importance for protein biosynthesis on ribosimes. We have examined the chemical synthesis and structural requirement of the 5′-terminus of mRNA. This paper describes a brief summary of the synthesis of the cap structure and the 5′-terminus of mRNA bearing the leader sequences.

Key concepts: Messenger RNA, Five-prime cap, RNA, Mature messenger RNA, Post-transcriptional modification, Chemistry, Protein biosynthesis, Rna processing

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