1998•IUBMB LifeRequires access

Effects of La3 on lipid fluidity and structural transitions in human erythrocyte membranes

Xinmin Li, Jiazuan Ni, Jianwen Chen, Fen Hwang

Abstract

The effects of La3+ on the structure and function of human erythrocyte membranes were investigated by fluorescence polarization, spin-labeled electron spin resonance (ESR) and differential scanning calorimetry (DSC). The results showed that increasing concentrations of La3+ inhibited (Na(+) + K+)-ATPase and Mg(2+)-ATPase activities. La3+ lowered the lipid fluidity of erythrocyte membranes and induced structural transitions in erythrocyte membranes.

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Key concepts: Membrane fluidity, Membrane, Fluorescence anisotropy, Differential scanning calorimetry, Erythrocyte membrane, Chemistry, Electron paramagnetic resonance, Biophysics