1974•Acta Pharmacologica et ToxicologicaRequires access

The Effect of NH4Cl on Polyuria and Polydipsia during Prolonged Lithium Administration in the Rat

Donald F. Smith

Abstract

Abstract:Polyuria and polydipsia developed in rats given water to drink and fed a diet containing lithium which maintained their serum lithium level between 0.45 and 0.65 meq./l for two weeks. Polyuria and polydipsia were completely prevented and partially cured in rats given the lithium‐containing diet and solutions of NH4Cl. Polyuria and polydipsia were partially prevented but not cured in rats given water and fed a diet containing lithium and NH4Cl. The possible mechanisms responsible for the effects of NH4Cl on polyuria and polydipsia in the rats given lithium are discussed.

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Key concepts: Polydipsia, Polyuria, Lithium (medication), Endocrinology, Internal medicine, Medicine, Chemistry, Diabetes mellitus