Early morphological brain abnormalities in patients with amnestic mild cognitive impairment

Abstract Patients with amnestic mild cognitive impairment (aMCI) are at an increased risk of further deterioration and eventually developing Alzheimer’s disease (AD). Therefore, the identification of specific markers for this disease such as radiological markers is of great diagnostic and clinical significance. Our previous work has shown that magnetic resonance imaging (MRI) is a powerful tool to identify unique imaging features in patients with aMCI. Herein, we calculated the gray matter volume by structural magnetic resonance imaging (sMRI), and spontaneous low frequency fluctuations (LFF) using resting-state functional MRI (rs-fMRI) in 11 patients with aMCI and 22 normal control patients. Compared with the control group, patients with aMCI showed significant reduction of gray matter volume in the inferior frontal gyrus, inferior parietal lobule, anterior cingulated cortex, and insula and superior temporal gyrus. Patients with aMCI also showed significantly lower amplitudes of low-frequency fluctuations (ALFF) in the posterior cingulate cortex, precuneus, temporal gyrus and inferior parietal lobule when compared with the control group. However, in several other brain regions including the occipital lobe and cerebellum, the ALFF in patients with aMCI was significantly increased. The variation in ALFF between the two groups remained significant after adjustment for structural differences. Our results obtained in this pilot study are consistent with our previous finding and collectively show that patients with aMCI have abnormal MRI imaging findings. The pathological basis of these imaging features in patients with aMCI needs to be further explored.