1979•Proceedings of the National Academy of SciencesOpen access
Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.
D A Carson, Jonathan Kaye, Steven S. Matsumoto, J. Edwin Seegmiller, L. Thompson
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Abstract
Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.
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