2005•Journal of PsychopharmacologyRequires access

Clozapine-induced type-2 diabetes mellitus: possible mechanisms and implications for clinical practice

Elizabeth Tovey, Hagen Rampes, Callum Livingstone

Abstract

The atypical antipsychotic clozapine has been reported to be associated with metabolic adverse effects, including type-2 diabetes mellitus. We present two cases of diabetes mellitus associated with clozapine treatment. One case resolved entirely upon withdrawal of the drug, whereas the other did not. We discuss the molecular basis of the diabetogenic action of clozapine and recommendations for monitoring.

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Key concepts: Clozapine, Antipsychotic, Medicine, Diabetes mellitus, Atypical antipsychotic, Antipsychotic drug, Type 2 Diabetes Mellitus, Drug