Coexistent Pernicious Anemia and Malabsorption in Four Patients

Article1 June 1966Coexistent Pernicious Anemia and Malabsorption in Four PatientsIncluding One Whose Malabsorption Disappeared with Vitamin B12 TherapyEUGENE A. BRODY, M.D., SOLOMON ESTREN, M.D., F.A.C.P., VICTOR HERBERT, M.D.EUGENE A. BRODY, M.D.Search for more papers by this author, SOLOMON ESTREN, M.D., F.A.C.P.Search for more papers by this author, VICTOR HERBERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1246 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvaluation of patients with megaloblastic anemia due to vitamin B12deficiency includes absorption studies using radioactive labeled vitamin B12and intrinsic factor. These studies are performed not only to prove or disprove a vitamin B12absorptive defect but also to distinguish between gastric intrinsic factor lack and small bowel dysfunction as etiologies for this absorptive defect. Vitamin B12deficiency is generally regarded as due to either one of these two factors. This report presents three patients in whom pernicious anemia and small bowel lesions associated with small intestinal malabsorption of vitamin B12coexisted, and a fourth in whom pernicious anemia...References1. ROSS GI: Vitamin B12 assay in body fluids using Euglena gracilis. J. Clin. Path. 5: 250, 1952. CrossrefMedlineGoogle Scholar2. LAUGOTTLIEBWASSERMANHERBERT KSCLRV: Measurement of serum vitamin B12 level using radioisotope dilution and coated charcoal. Blood 26: 202, 1965. CrossrefMedlineGoogle Scholar3. HERBERT V: Aseptic addition method for Lactobacillus casei assay of folate activity in human serum. J. Clin. Path. 19: 12, 1966. CrossrefMedlineGoogle Scholar4. SCHILLING RF: Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J. Lab. Clin. Med. 42: 960, 1953. Google Scholar5. GLASSBOYDGELLINSTEPHANSON GBLJGAL: Uptake of radioactive vitamin B12 by the liver in humans: test for measurement of intestinal absorption of vitamin B12 and intrinsic factor activity. Arch. Biochem. 51: 251, 1954. CrossrefMedlineGoogle Scholar6. GOTTLIEBLAUWASSERMANHERBERT CKSLRV: Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B12 binding capacity, antibody to IF, and serum unsaturated B12 binding capacity. Blood 25: 875, 1965. CrossrefMedlineGoogle Scholar7. RAMSEYHERBERT CV: Dialysis assay for intrinsic factor and its antibody: demonstration of species specificity of antibodies to human and hog intrinsic factor. J. Lab. Clin. Med. 65: 143, 1965. MedlineGoogle Scholar8. CROSBYKUGLER WHHW: Intraluminal biopsy of small intestine: intestinal biopsy capsule. Amer. J. Dig. Dis. 2: 236, 1957. CrossrefMedlineGoogle Scholar9. BEZMANKINNEARZAMCHECK ADGN: D-xylose and potassium iodide absorption and serum carotene in pernicious anemia. J. Lab. Clin. Med. 53: 226, 1959. MedlineGoogle Scholar10. BRUMMERHARRI PJ: Plasma vitamin A level and the vitamin A absorption test in achlorhydria. Acta Med. Scand. 167: 287, 1960. CrossrefMedlineGoogle Scholar11. HAURANISHERWOODGOLDSTEIN FIWF: Intestinal malabsorption of vitamin B12 in pernicious anemia. Metabolism 13: 1342, 1964. CrossrefMedlineGoogle Scholar12. THAYSEN TE: Non-tropical Sprue. Oxford University Press, London, 1932. Google Scholar13. CASTLERHOADSLAWSONPAYNE WBCPHAGC: Etiology and treatment of sprue; observations on patients in Puerto Rico and subsequent experiments on animals. Arch. Intern. Med. (Chicago) 56: 627, 1935. CrossrefGoogle Scholar14. VAISHSAMPATHKUMARJACOBBAKER SKJRSJ: The stomach in tropical sprue. Gut 6: 458, 1965. CrossrefMedlineGoogle Scholar15. FONECOOKEMEYNELLHARRIS DJWTMJEL: CO58B12 absorption (hepatic surface count) after gastrectomy, ileal resection, and in coeliac disorders. Gut 2: 218, 1961. CrossrefMedlineGoogle Scholar16. REYNOLDSHALLPIKEPHILLIPSMATTHEWS EHJFBMDM: Reversible absorptive defects in anticonvulsant megaloblastic anemia. J. Clin. Path. 18: 593, 1965. CrossrefMedlineGoogle Scholar17. LAWRENCE C: B12 binding protein deficiency in pernicious anemia. Blood 27: 389, 1966. CrossrefMedlineGoogle Scholar18. GOTTLIEBRETIEFPRATTHERBERT CWFPPWV: Correlation of B12 binding proteins with disorders of B12 metabolism: relation to hypo- and hyper-leucocytic states and leucocyte turnover. J. Clin. Invest. 44: June, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Hematology, The Mount Sinai Hospital, New York, N. Y.This work was supported by research grants AM 09564 and AM 09062 from the National Institute of Arthritis and Metabolic Diseases, the National Institutes of Health, Bethesda, Md., research grant FR-71 from the Division of Research Facilities and Resources, the U. S. Public Health Service, Washington, D. C., and grants from the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Funds (of the Mount Sinai Hospital).Dr. Herbert is the recipient of Career Scientist Award I-435 from the Health Research Council of the City of New York.This paper was presented in part before the open program of the Committee of the American Society of Hematology on Vitamin B12 and Folic Acid, at the Eighth Annual Meeting of the American Society of Hematology, Philadelphia, Pa., December 5, 1965.Requests for reprints should be addressed to Eugene A. Brody, M. D., The Mount Sinai Hospital, New York, N. Y. 10029. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis of Megaloblastic AnemiaAnemia and abnormal upper gastrointestinal study in a 15-year-old adolescentVitamin B12 and Folic Acid: Clinical and Pathophysiological ConsiderationsThe Hematopoietic SystemImmunological Dysfunction with Atrophic Gastritis and Gastric MalignancyIntestinal absorptive and digestive function in pernicious anemiaNutritional Anemias Overview; Megaloblastic AnemiasSpurious Schilling Test Results Obtained with Intrinsic Factor Enclosed in CapsulesJ. W. D. McDONALD, M.D., F.R.C.P.(C), Ph.D., R. M. BARR, M.D., F.R.C.P.(C), W. B. 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TWOMEY, M.D.Intestinal structure and function in megaloblastic anemia in adultsVitamin B12 absorption in some neurological and neuroendocrine disordersAbsorption and malabsorption of vitamin B12Eosinophilic GastroenteritisThe syndrome of immunoglobulin deficiency and pernicious anemiaClinical Observations on MalabsorptionTRANSIENT (REVERSIBLE) MALABSORPTION OF VITAMIN B 12PERNICIOUS ANAEMIA AS A CAUSE OF DIARRHOEAMalabsorption in Pernicious AnemiaMUNSEY S. WHEBY, M.D., F.A.C.P.Current Views on Tropical Sprue and a Comparison to Nontropical SprueStudies on Two Patients with Concomitant Intrinsic Factor Secretory Defect and Jejunal DiverticulosisPernicious Anemia and Immunologic DeficiencyHAROLD O. CONN, M.D., HENRY BINDER, M.D., BRANTLEY BURNS, M.D.Absorption of Vitamin B12 and Folic AcidCorrectable Intestinal Defect of Vitamin B12 Absorption in Pernicious AnemiaRALPH CARMEL, M.D., VICTOR HERBERT, M.D.Mucosa of the Small Intestine in Pernicious AnemiaStudies on Two Patients with Concomitant Pernicious Anemia and Immunoglobulin DeficiencyROBERT CLARK, KARL TORNYOS, M.D., VICTOR HERBERT, M.D., JEREMIAH J. TWOMEYIntrinsic Factor Inhibitors, Pernicious Anemia, and Autoimmunity 1 June 1966Volume 64, Issue 6Page: 1246-1251KeywordsAnemiaHematology and oncologyHospitalsLesionsMetabolic disordersPernicious anemiaResearch facilitiesResearch grantsScientistsVitamin B12 deficiency ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...