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1977•Acta Pathologica Microbiologica Scandinavica Section C ImmunologyRequires access

CONCANAVALIN A‐INDUCED ACTIVATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS MEMORY LYMPHOCYTES INTO SPECIFICALLY CYTOTOXIC T CELLS

O Marker, Allan Randrup Thomsen, Grethe Thörner Andersen

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Abstract

When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

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What this paper is about

When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

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Available abstract

When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A. highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A-stimulated cells is higher than that of non-incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti-theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.

Key concepts: Lymphocytic choriomeningitis, Cytotoxic T cell, Effector, Concanavalin A, Spleen, Cytotoxicity, Biology, In vitro

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CONCANAVALIN A‐INDUCED ACTIVATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS MEMORY LYMPHOCYTES INTO SPECIFICALLY CYTOTOXIC T CELLS — Research Paper | ScholarLens