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Hemoglobin Maputo : A New 6-Chain Variant (α2β2 47 (Cd6) Asp→Tyr) in Combination with Hemoglobin S, Identified by High Performance Liquid Chromatography (Hplc)

M Marinucci, Jean‐Paul Boissel, Alessandra Massa, Henri Wajcman, L Tentori, Dominique Labie

Abstract

During a routine hematological investigation, a slowly-moving hemoglobin variant was detected in a 2-year-old child from Maputo (Mozambique) in combination with hemoglobin S. Structural studies carried out by HPLC demonstrated a previously unreported amino acid substitution, beta 47 (CD6) Asp replaced by Tyr. The new hemoglobin variant has been named hemoglobin Maputo.

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Key concepts: Hemoglobin, Hemoglobin variants, High-performance liquid chromatography, Hemoglobin s, Amino acid substitution, Hemoglobinopathy, Chemistry, Chromatography