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2013•Reviews in Medical MicrobiologyOpen access

Mechanisms of hepatitis B virus-induced hepatocellular carcinoma

Sohrab Boozarpour, Mansour Mashreghi, Mahdi Mirahmadi

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common fatal cancers in the world and hepatitis B virus (HBV) is one of the major causes of HCC. The pathogenesis of HBV-related HCC, however, has not been fully examined. HBV induces HCC by genome integration and expression of trans-activating factors derived from the HBV genome. Evidence suggests that the HBV X protein (HBx) plays an essential role in the pathogenesis of HCC. We have reviewed the mechanism of hepatocarcinogenesis at the molecular level with a particular emphasis on the role of X protein.

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What this paper is about

Hepatocellular carcinoma (HCC) is one of the most common fatal cancers in the world and hepatitis B virus (HBV) is one of the major causes of HCC. The pathogenesis of HBV-related HCC, however, has not been fully examined. HBV induces HCC by genome integration and expression of trans-activating factors derived from the HBV genome. Evidence suggests that the HBV X protein (HBx) plays an essential role in the pathogenesis of HCC. We have reviewed the mechanism of hepatocarcinogenesis at the molecular level with a particular emphasis on the role of X protein.

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Available abstract

Hepatocellular carcinoma (HCC) is one of the most common fatal cancers in the world and hepatitis B virus (HBV) is one of the major causes of HCC. The pathogenesis of HBV-related HCC, however, has not been fully examined. HBV induces HCC by genome integration and expression of trans-activating factors derived from the HBV genome. Evidence suggests that the HBV X protein (HBx) plays an essential role in the pathogenesis of HCC. We have reviewed the mechanism of hepatocarcinogenesis at the molecular level with a particular emphasis on the role of X protein.

Key concepts: HBx, Hepatocellular carcinoma, Hepatitis B virus, Pathogenesis, Virology, Mechanism (biology), Genome, Hepatitis B

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