1975Scandinavian Journal of ImmunologyRequires access

The P‐Component of Amyloid of Human Islets of Langerhans

Per Westermark, M Skinner, Alan S. Cohen

Open publisher page 54 citations

Abstract

The P-component of amyloid was found in extracts of pancreases with islet amyloidosis. In double immunodiffusion this P-component showed lines of identity with isolated purified human P-component, normal human serum, and an extract of amyloid-rich liver tissue from a patient with primary systemic amyloidosis. The finding supports the theory that the P-component is present in all native human amyloid irrespective of type.

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What this paper is about

The P-component of amyloid was found in extracts of pancreases with islet amyloidosis. In double immunodiffusion this P-component showed lines of identity with isolated purified human P-component, normal human serum, and an extract of amyloid-rich liver tissue from a patient with primary systemic amyloidosis. The finding supports the theory that the P-component is present in all native human amyloid irrespective of type.

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Available abstract

The P-component of amyloid was found in extracts of pancreases with islet amyloidosis. In double immunodiffusion this P-component showed lines of identity with isolated purified human P-component, normal human serum, and an extract of amyloid-rich liver tissue from a patient with primary systemic amyloidosis. The finding supports the theory that the P-component is present in all native human amyloid irrespective of type.

Key concepts: Serum amyloid P component, Amyloid (mycology), Islet, Immunodiffusion, Amyloidosis, Component (thermodynamics), Human liver, Amyloid fibril

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