2000•CardiologyRequires access

Rhabdomyolysis and Acute Renal Failure after Changing Statin-Fibrate Combinations

J. Bradley Oldemeyer, Richard Lund, Matt Koch, A Meares, Robert Dunlay

Abstract

Statin-fibrate combinations are commonly used to treat hyperlipidemia. These drugs have been previously reported to cause rhabdomyolysis with acute renal failure. Whether different statin-fibrate combinations have different risks for rhabdomyolysis is not known. We report a patient who developed rhabdomyolysis with acute renal failure promptly after switching from the combination of pravastatin and fenofibrate to simvastatin and gemfibrozil.

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Key concepts: Fibrate, Rhabdomyolysis, Medicine, Statin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Internal medicine, Intensive care medicine, Acute kidney injury