2009•DigestionRequires access

Inhibition of Human Gastric Acid Secretion by Peptide YY and Secretin

Ole Olsen, John Christiansen

Abstract

In 6 healthy volunteers we investigated the effect of secretin and peptide YY (PYY) on gastric acid secretion stimulated by pentagastrin (100 ng/kg/h). Secretin (0.05 CU/kg/h) and PYY (10.0 pmol/kg/h) were given intravenously either alone or in combination. Given alone secretin and PYY inhibited gastric acid output by 25 and 21%, respectively. The combined infusion of secretin and PYY inhibited acid output by 38% indicating an additive effect. The infusion of one hormone did not influence release of the other. It is suggested that the interaction of PYY and secretin on pentagastrin-stimulated gastric acid secretion in normal man is of the additive type.

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Key concepts: Secretin, Peptide YY, Pentagastrin, Internal medicine, Endocrinology, Gastric acid, Gastrointestinal hormone, Secretion