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2012•Bioscience Biotechnology and BiochemistryOpen access

Severe Inhibition ofin VitroCardiomyogenesis in Mouse Embryonic Stem Cells Ectopically Expressing EGAM1C Homeoprotein

Momoe Iha, Miki Soma, Sho Sato, Yuki Mori, Saiko Sugawara, Kano Kasuga, Ikuo Kojima, Satoshi Yamada, Shujiro Sakaki, Masayuki Kobayashi

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Abstract

Embryoid bodies were prepared from mouse embryonic stem cells expressing exogenous EGAM1C to analyze their ability to differentiate toward terminally differentiated cell types. The generation of cardiomyocytes was severely suppressed in Egam1c transfectants without upregulation of Nkx2-5, a crucial gene for cardiomyogenesis. These results indicate that EGAM1C is capable of affecting terminal differentiation in mouse embryonic stem cells.

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What this paper is about

Embryoid bodies were prepared from mouse embryonic stem cells expressing exogenous EGAM1C to analyze their ability to differentiate toward terminally differentiated cell types. The generation of cardiomyocytes was severely suppressed in Egam1c transfectants without upregulation of Nkx2-5, a crucial gene for cardiomyogenesis. These results indicate that EGAM1C is capable of affecting terminal differentiation in mouse embryonic stem cells.

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Available abstract

Embryoid bodies were prepared from mouse embryonic stem cells expressing exogenous EGAM1C to analyze their ability to differentiate toward terminally differentiated cell types. The generation of cardiomyocytes was severely suppressed in Egam1c transfectants without upregulation of Nkx2-5, a crucial gene for cardiomyogenesis. These results indicate that EGAM1C is capable of affecting terminal differentiation in mouse embryonic stem cells.

Key concepts: Embryoid body, Embryonic stem cell, Cell biology, Stem cell, Downregulation and upregulation, In vitro, Biology, Cellular differentiation

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Severe Inhibition ofin VitroCardiomyogenesis in Mouse Embryonic Stem Cells Ectopically Expressing EGAM1C Homeoprotein — Research Paper | ScholarLens