1966•ScienceRequires access
Response : Measurement of Anesthetic Potency
Arthur Cherkin, J. F. Catchpool
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Abstract
In "Temperature dependence of anesthesia in goldfish" (l), Cherkin and Catchpool introduce a technique for making quantitative measurements of the anesthetic potency of water-soluble agents. Goldfish are kept swimming by an applied stimulus (an electric shock); anesthetic potency is measured as AD_(50) the dose at which 50 percent of the experimental animals fail to respond to the stimulus.