2-Acetylaminofluorene induces forms of cytochrome P-450 active in its own metabolism

The effect of short-term treatment of rats with 2-acetylaminofluorene on the metabolism of this same compound by liver microsomes has been investigated. This treatment was found to increase the formation of 7-, 9-, and N-hydroxy-2-acetylaminofluorene 3-4 fold. The largest effect was seen in the formation of 5- and 3-hydroxy-2-acetylaminofluorene, which increased 105- and 27.3-fold, respectively. There was no significant increase in the formation of 1-hydroxy-2-acetylaminofluorene.